![]() ![]() It is of vital importance that compounds intended for use in humans are adequately tested in suitable animal systems. mellonella larvae can be used in infectivity trials and toxicity testing, and that these assays represent an inexpensive and readily executable alternative to testing in rodents. Again we found a good correlation between toxicity in Galleria and that in rodents. Similarly, we have assessed 11 compounds (initially tested blind) for their toxicity in Galleria and compared this with toxicity trials in mice and rats. Using four bacterial species (two Gram-negative and two Gram-positive) we have assessed the efficacy of four antibiotics against infections in Galleria and compared the antibiotic susceptibility with that in humans. We have assessed the use of these insects in infectivity trials and toxicity testing. Galleria mellonella (greater wax moth) larvae are a potential alternative. However, trials in rats and mice are expensive and there are ethical considerations. ![]() Infectivity trials and toxicity testing in rodents are important prerequisites to the use of compounds in man. ![]()
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